The Yaquina River (English pronunciation: /jəˈkwɪnə/ yə-kwin-ə) is a river, approximately 50 mi (80 km) long, on the Pacific coast of Oregon in the United States. It drains an area of the Central Oregon Coast Range west of the Willamette Valley near Newport.
It rises in the mountains west of Corvalllis, in the Siuslaw National Forest along the county line between Benton and Lincoln counties at . It flows south, then generally west, in a highly serpentine course, past Toledo. It enters the Pacific in Yaquina Bay, a broad estuary at Newport. The Yaquina Bay Lighthouse is located on the coast near the mouth of the river.